Mokhoa o ts'episang bakeng sa Mafu a Neurodegenerative: Hyperbaric Oxygen Therapy

Ho utloisisa Hyperbaric Oxygen Therapy (HBOT)

HBOT e atisa ho kenyelletsa khatello e ntseng e eketseha ho ea holimo ho 1 absolute atmosphere (ATA) - khatello e boemong ba leoatle - ka nako ea metsotso ea 90-120, hangata e hlokang linako tse ngata ho itšetlehile ka boemo bo itseng bo phekoloang. Khatello ea moea e matlafalitsoeng e ntlafatsa phano ea oksijene liseleng, e leng eona e susumetsang ho ata ha lisele tsa stem le ho matlafatsa mekhoa ea pholiso e kenelletseng ke lintlha tse itseng tsa kholo.

Qalong, ts'ebeliso ea HBOT e thehiloe holim'a molao oa Boyle-Marriott, o fanang ka phokotso e itšetlehileng ka khatello ea li-bubble tsa khase, hammoho le melemo ea boemo bo phahameng ba oksijene liseleng. Ho na le mefuta e mengata ea li-pathologies tse tsejoang hore li rua molemo ho boemo ba hyperoxic bo hlahisoang ke HBOT, ho kenyelletsa le lisele tsa necrotic, likotsi tsa mahlaseli a kotsi, ho sithabela maikutlo, ho chesa, compartment syndrome, le gas gangrene, har'a tse ling tse thathamisitsoeng ke Undersea le Hyperbaric Medical Society. Haholo-holo, HBOT e boetse e bontšitse katleho e le phekolo ea tlatsetso mefuteng e fapaneng ea mafu a ho ruruha kapa a tšoaetsanoang, a kang colitis le sepsis. Ka lebaka la mekhoa ea eona e khahlanong le ho ruruha le ea oxidative, HBOT e fana ka monyetla oa bohlokoa e le mokhoa oa ho phekola mafu a neurodegenerative.

 

Lithuto tsa Preclinical tsa Hyperbaric Oxygen Therapy ho Neurodegenerative Diseases: Lintlha tse tsoang ho 3 × Tg Mouse Model

E 'ngoe ea lithuto tse hlokomelehange tsepamisitse maikutlo ho mofuta oa mouse oa 3×Tg oa lefu la Alzheimer's (AD), le ileng la bontša bokhoni ba phekolo ea HBOT ho ntlafatsa bofokoli ba kelello. Patlisiso e ne e kenyelletsa litoeba tsa 3 × Tg tsa likhoeli tse 17 ha li bapisoa le litoeba tsa C57BL / 6 tsa likhoeli tse 14 tse sebetsang e le taolo. Phuputso e bontšitse hore HBOT ha ea ka ea ntlafatsa ts'ebetso ea ts'ebetso ea kelello feela empa e boetse e fokotsa haholo ho ruruha, phallo ea plaque, le Tau phosphorylation-e leng mokhoa o boima o amanang le lefu la AD.

Liphello tsa tšireletso tsa HBOT li ne li bakoa ke ho fokotseha ha neuroinflammation. Sena se ile sa pakoa ke phokotso ea ho ata ha microglial, astrogliosis, le secretion ea pro-inflammatory cytokines. Liphuputso tsena li totobatsa karolo e 'meli ea HBOT ho ntlafatsa ts'ebetso ea kelello ha ka nako e ts'oanang e fokotsa mekhoa ea methapo ea methapo e amanang le lefu la Alzheimer's.

Mohlala o mong oa preclinical o sebelisitsoeng litoeba tsa 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) ho lekola mekhoa ea ts'ireletso ea HBOT mabapi le tšebetso ea neuronal le matla a motlakase. Liphetho li bonts'itse hore HBOT e kentse letsoho ho ntlafatseng ts'ebetso ea makoloi le matla a ho ts'oara litoeba tsena, e tsamaellanang le keketseho ea matšoao a mitochondrial biogenesis, haholoholo ka ts'ebetso ea SIRT-1, PGC-1α, le TFAM. Sena se totobatsa karolo ea bohlokoa ea ts'ebetso ea mitochondrial litlamorao tsa neuroprotective tsa HBOT.

 

Mekhoa ea HBOT ho mafu a Neurodegenerative

Molao-motheo oa ho sebelisa HBOT bakeng sa li-NDD o kamanong e teng lipakeng tsa phepelo ea oksijene e fokotsehileng le ho ba le monyetla oa liphetoho tsa neurodegenerative. Hypoxia-inducible factor-1 (HIF-1) e bapala karolo ea mantlha e le ntho e etsang hore liselefouno li ikamahanye le khatello e tlase ea oksijene 'me e kenyelelitsoe ho li-NDD tse fapaneng ho kenyeletsoa AD, PD, Boloetse ba Huntington le ALS, ho e tšoaea e le sepheo sa bohlokoa sa lithethefatsi.

Ka lebaka la hore lilemo ke sesosa se seholo sa kotsi bakeng sa mafu a mangata a neurodegenerative, ho etsa lipatlisiso ka phello ea HBOT ho neurobiology ea botsofali ho bohlokoa. Liphuputso li bontšitse hore HBOT e ka ntlafatsa bofokoli ba kelello bo amanang le lilemo ho batho ba hōlileng ba phetseng hantle.Ho feta moo, bakuli ba tsofetseng ba nang le mathata a bohlokoa a ho hopola ba bontšitse ntlafatso ea kelello le ho eketseha ha mali a boko ka mor'a ho pepesehela HBOT.

 

1. Tšusumetso ea HBOT ho Inflammation le Oxidative Stress

HBOT e bontšitse bokhoni ba ho fokotsa neuroinflammation ho bakuli ba nang le bothata bo matla ba boko. E na le matla a ho theola li-cytokine tsa pro-inflammatory (tse kang IL-1β, IL-12, TNFα, le IFNγ) ha e ntse e laola li-cytokine tse khahlanong le ho ruruha (joaloka IL-10). Bafuputsi ba bang ba fana ka maikutlo a hore mefuta e mengata ea oksijene e sebetsang (ROS) e hlahisoang ke HBOT e kenyelletsa litlamorao tse 'maloa tse molemo tsa kalafo. Ka lebaka leo, ntle le ketso ea eona ea ho fokotsa bubble e itšetlehileng ka khatello le ho fumana ho tlala ha oksijene ea lisele tse phahameng, liphello tse ntle tse amanang le HBOT li itšetlehile ka karolo ea mesebetsi ea 'mele ea ROS e hlahisoang.

2. Liphello tsa HBOT ho Apoptosis le Neuroprotection

Lipatlisiso li bontšitse hore HBOT e ka fokotsa phosphorylation ea hippocampal ea p38 mitogen-activated protein kinase (MAPK), ka mor'a moo ea ntlafatsa tsebo le ho fokotsa tšenyo ea hippocampal. Ka bobeli HBOT e ikemetseng le e kopantsoeng le Ginkgo biloba extract e fumanoe e theola polelo ea Bax le mosebetsi oa caspase-9/3, e leng se fellang ka ho fokotseha ha litekanyetso tsa apoptosis mefuteng ea litoeba tse susumelitsoeng ke aβ25-35. Ho feta moo, phuputso e 'ngoe e bontšitse hore HBOT preconditioning e bakile mamello khahlanong le cerebral ischemia, ka mekhoa e amanang le ho eketseha ha polelo ea SIRT1, hammoho le maemo a eketsehileng a B-cell lymphoma 2 (Bcl-2) le ho fokotsa caspase-3 e sebetsang, e totobatsang thepa ea neuroprotective le anti-apoptotic ea HBOT.

3. Tšusumetso ea HBOT ho Potoloho leNeurogenesis

Ho pepesa bafo ho HBOT ho amahanngoa le litlamorao tse ngata tsamaisong ea methapo ea mali, ho kenyelletsa le ho matlafatsa thibelo ea mali le boko, ho khothaletsa angiogenesis, le ho fokotsa edema. Ntle le ho fana ka phepelo e eketsehileng ea oksijene ho lisele, HBOTe matlafatsa sebopeho sa methapo ea malika ho kenya tšebetsong lintlha tse ngotsoeng tse kang vascular endothelial growth factor le ka ho susumetsa ho ata ha lisele tsa neural stem.

4. Liphello tsa Epigenetic tsa HBOT

Liphuputso li senoletse hore ho pepeseha ha lisele tsa "microvascular endothelial" tsa motho (HMEC-1) ho oksijene ea hyperbaric e laola haholo liphatsa tsa lefutso tsa 8,101, ho kenyelletsa le lipolelo tse peli tse laoloang le tse fokolitsoeng, tse totobatsang keketseho ea liphatsa tsa lefutso tse amanang le litsela tsa ho arabela antioxidant.