Mokhoa o Tšepisang bakeng sa Mafu a ho Fokotsa Methapo ea Kelello: Kalafo ea Oksijene e Feteletseng

Ho Utloisisa Kalafo ea Oksijene ea Hyperbaric (HBOT)

Hangata HBOT e kenyelletsa ho eketsa khatello ho ea ho sepakapaka se kaholimo ho 1 (ATA) - khatello boemong ba leoatle - ka nako ea metsotso e 90-120, hangata e hloka linako tse ngata ho latela boemo bo itseng bo phekoloang. Khatello e eketsehileng ea moea e ntlafatsa ho tsamaisoa ha oksijene liseleng, e leng se susumetsang ho ata ha lisele tsa stem le ho ntlafatsa lits'ebetso tsa pholiso tse tsamaisoang ke mabaka a itseng a kholo.

Qalong, tshebediso ya HBOT e ne e thehilwe hodima molao wa Boyle-Marriott, o bolelang phokotso e itshetlehileng kgatellong ya dipululana tsa kgase, hammoho le melemo ya maemo a phahameng a oksijene dinama. Ho na le mefuta e fapaneng ya mafu a tsejwang a ruang molemo boemong ba hyperoxic bo hlahiswang ke HBOT, ho kenyeletswa dinama tse tshwerweng ke lefu la ho bola, dikotsi tsa mahlaseli a kotsi, kotsi, ho tjheswa, compartment syndrome, le gangrene ya kgase, hara tse ding tse thathamisitsweng ke Undersea le Hyperbaric Medical Society. Haholoholo, HBOT e boetse e bontshitse katleho e le kalafo e tlatsetsang mefuteng e fapaneng ya mafu a tshwaetsanang a ho ruruha kapa a tshwaetsanang, jwalo ka colitis le sepsis. Ka lebaka la mekgwa ya yona ya ho lwantsha ho ruruha le oxidative, HBOT e fana ka bokgoni bo boholo e le tsela ya kalafo bakeng sa mafu a methapo.

 

Lithuto tsa Pele ho Kliniki tsa Kalafo ea Oksijene ea Hyperbaric ho Mafu a Neurodegenerative: Temohisiso e tsoang ho Mohlala oa Mouse oa 3 × Tg

E 'ngoe ea lithuto tse tsebahalange ne e shebane le mohlala oa litoeba tsa 3×Tg tsa lefu la Alzheimer's (AD), tse bontšitseng bokhoni ba HBOT ba ho phekola ho fokotsa likhaello tsa kelello. Phuputso e ne e kenyelletsa litoeba tse tona tsa likhoeli tse 17 tsa 3×Tg ha li bapisoa le litoeba tse tona tsa likhoeli tse 14 tsa C57BL/6 tse sebetsang e le taolo. Phuputso e bontšitse hore HBOT ha ea ntlafatsa feela ts'ebetso ea kelello empa hape e fokolitse ho ruruha haholo, mojaro oa plaque, le phosphorylation ea Tau—mokhoa oa bohlokoa o amanang le lefu la AD.

Litlamorao tsa tšireletso tsa HBOT li bakiloe ke ho fokotseha ha ho ruruha ha methapo ea kutlo. Sena se pakoa ke phokotso ea ho ata ha microglial, astrogliosis, le ho ntšoa ha li-cytokine tse bakang ho ruruha. Liphuputso tsena li totobatsa karolo e habeli ea HBOT ho ntlafatseng ts'ebetso ea kelello ha ka nako e ts'oanang e fokotsa lits'ebetso tsa ho ruruha ha methapo tse amanang le lefu la Alzheimer's.

Mohlala o mong wa pele ho tleliniki o sebedisitse ditoeba tsa 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) ho lekola mekgwa ya tshireletso ya HBOT mosebetsing wa methapo ya kutlo le bokgoni ba ho tsamaisa mesifa. Diphetho di bontshitse hore HBOT e kentse letsoho ho ntlafatseng tshebetso ya mesifa le matla a ho tshwara ditoeba tsena, tse amanang le keketseho ya ho tshwaya ha mitochondrial biogenesis, haholoholo ka ho kenngwa tshebetsong ha SIRT-1, PGC-1α, le TFAM. Sena se totobatsa karolo ya bohlokwa ya mosebetsi wa mitochondrial ditlamoraong tsa tshireletso ya methapo ya kutlo tsa HBOT.

 

Mekhoa ea HBOT ho Mafu a Neurodegenerative

Molao-motheo oa motheo oa ho sebelisa HBOT bakeng sa li-NDD o lutse kamanong e pakeng tsa phepelo e fokotsehileng ea oksijene le ho ba kotsing ea liphetoho tsa methapo. Hypoxia-inducible factor-1 (HIF-1) e bapala karolo ea bohlokoa e le transcription factor e nolofalletsang ho ikamahanya le sele khatellong e tlase ea oksijene 'me e' nile ea ameha ho li-NDD tse fapaneng ho kenyeletsoa AD, PD, Lefu la Huntington le ALS, e leng se e tšoaeang e le sepheo sa bohlokoa sa lithethefatsi.

Ka lebaka la hore botsofali ke sesosa se seholo sa kotsi bakeng sa mafu a mangata a methapo ea kutlo, ho batlisisa tšusumetso ea HBOT ho neurobiology ea botsofali ho bohlokoa. Lithuto li bontšitse hore HBOT e ka ntlafatsa likhaello tsa kelello tse amanang le botsofali ho batho ba baholo ba phetseng hantle.Ho phaella moo, bakuli ba hōlileng ba nang le mathata a maholo a ho hopola ba bontšitse ntlafatso ea kelello le keketseho ea phallo ea mali bokong ka mor'a ho pepesehela HBOT.

 

1. Tšusumetso ea HBOT holim'a ho ruruha le khatello ea maikutlo ea oxidative

HBOT e bontšitse bokhoni ba ho fokotsa ho ruruha ha methapo ea kutlo ho bakuli ba nang le bothata bo boholo ba boko. E na le bokhoni ba ho fokotsa li-cytokine tse bakang ho ruruha (tse kang IL-1β, IL-12, TNFα, le IFNγ) ha e ntse e fokotsa li-cytokine tse thibelang ho ruruha (joalo ka IL-10). Bafuputsi ba bang ba fana ka maikutlo a hore mefuta ea oksijene e arabelang (ROS) e hlahisoang ke HBOT e na le litlamorao tse 'maloa tse molemo tsa phekolo. Ka lebaka leo, ntle le ketso ea eona ea ho fokotsa lipululana e itšetlehileng ka khatello le ho fihlela ho tlala ha oksijene e ngata liseleng, liphello tse ntle tse amanang le HBOT li itšetlehile ka karolo ea 'mele ea ROS e hlahisoang.

2. Litlamorao tsa HBOT ho Apoptosis le Tšireletso ea Neuro

Lipatlisiso li bontšitse hore HBOT e ka fokotsa phosphorylation ea hippocampal ea p38 mitogen-activated protein kinase (MAPK) e kentsoeng tšebetsong ke mitogen, ka mor'a moo ea ntlafatsa kutloisiso le ho fokotsa tšenyo ea hippocampal. Ho fumanoe hore HBOT e ikemetseng le hammoho le Ginkgo biloba extract li fokotsa tlhahiso ea Bax le ts'ebetso ea caspase-9/3, e leng se fellang ka ho fokotseha ha sekhahla sa apoptosis mehlaleng ea litoeba e bakoang ke aβ25-35. Ho feta moo, phuputso e 'ngoe e bontšitse hore HBOT e lokisang esale pele e bakile mamello khahlanong le ischemia ea boko, ka mekhoa e kenyeletsang keketseho ea tlhahiso ea SIRT1, hammoho le maemo a eketsehileng a B-cell lymphoma 2 (Bcl-2) le phokotso ea caspase-3 e sebetsang, e totobatsang thepa ea HBOT ea ho sireletsa methapo le ho thibela apoptotic.

3. Tšusumetso ea HBOT ho Potoloho ea Mali leNeurogenesis

Ho pepesetsa batho ba nang le HBOT ho 'nile ha amahanngoa le liphello tse ngata tsamaisong ea methapo ea mali ea hlooho, ho kenyeletsoa le ho ntlafatsa ho kenella ha thibelo ea mali bokong, ho khothalletsa angiogenesis, le ho fokotsa ho ruruha. Ntle le ho fana ka phepelo e eketsehileng ea oksijene liseleng, HBOTe khothalletsa ho thehoa ha methapo ea malika ho kenya tshebetsong dintho tse kang vascular endothelial growth factor le ka ho susumetsa ho ata ha disele tsa methapo ya kutlo.

4. Litlamorao tsa Epigenetic tsa HBOT

Lithuto li senotse hore ho pepesehela lisele tsa endothelial tsa methapo ea mali ea motho (HMEC-1) ho oksijene e nang le hyperbaric ho laola liphatsa tsa lefutso tse 8,101 haholo, ho kenyeletsoa le ho phahama ha tlhahiso le ho fokotseha ha tlhahiso, ho totobatsa keketseho ea tlhahiso ea liphatsa tsa lefutso e amanang le litsela tsa karabelo ea antioxidant.