Sebakeng sa meriana ea morao-rao, lithibela-mafu li ipakile e le e 'ngoe ea tsoelo-pele ea bohlokoa ka ho fetisisa, e theolang sekhahla sa liketsahalo le ho shoa ho amanang le mafu a likokoana-hloko. Bokhoni ba bona ba ho fetola liphello tsa kliniki tsa tšoaetso ea baktheria bo ekelitse nako ea bophelo ea bakuli ba se nang palo. Lithibela-mafu li bohlokoa lits'ebetsong tse rarahaneng tsa bongaka, ho kenyelletsa opereishene, ho kenya li-implant, li-transplant le chemotherapy. Leha ho le joalo, ho hlaha ha likokoana-hloko tse hanyetsanang le lithibela-mafu e ’nile ea e-ba taba e ntseng e eketseha, e fokotsang matla a meriana ena ha nako e ntse e ea. Maemo a ho hanyetsa lithibela-mafu a ngotsoe likarolong tsohle tsa lithibela-mafu ha liphetoho tsa likokoana-hloko li etsahala. Khatello ea khetho e hlahisoang ke meriana e thibelang likokoana-hloko e tlatselitse ho eketseha ha mefuta e hanyetsanang, e leng se bakang phephetso e kholo bophelong ba lefatše lohle.
Ho loantša bothata bo matla ba ho hanyetsa likokoana-hloko, ho bohlokoa ho kenya ts'ebetsong melaoana e sebetsang ea taolo ea tšoaetso e fokotsang ho ata ha likokoana-hloko tse itoanelang, hammoho le ho fokotsa tšebeliso ea lithibela-mafu. Ho feta moo, ho na le tlhokahalo e potlakileng ea mekhoa e meng ea phekolo. Hyperbaric Oxygen Therapy (HBOT) e hlahile e le mokhoa o ts'episang moelelong ona, o kenyelletsang ho inhalation ea 100% ea oksijene maemong a itseng a khatello ka nako e itseng. Kaha HBOT e nkiloe e le phekolo ea mantlha kapa e tlatselletsang bakeng sa tšoaetso, e ka fana ka tšepo e ncha ea ho phekola mafu a hlabang a bakoang ke likokoana-hloko tse hananang le lithibela-mafu.
Kalafo ena e ntse e sebelisoa ka ho eketsehileng e le phekolo ea mantlha kapa e 'ngoe bakeng sa maemo a sa tšoaneng, ho akarelletsa le ho ruruha, chefo ea carbon monoxide, maqeba a sa foleng, mafu a ischemic le tšoaetso. Ts'ebeliso ea bongaka ea HBOT kalafong ea ts'oaetso e tebile, e fana ka melemo ea bohlokoa ho bakuli.
Likopo tsa Clinical tsa Hyperbaric Oxygen Therapy in Infection
Bopaki ba hona joale bo tšehetsa ka matla ts'ebeliso ea HBOT, ka bobeli e le phekolo e ikemetseng le e tlatsetsang, e fanang ka melemo e mengata ho bakuli ba nang le tšoaetso. Nakong ea HBOT, khatello ea mali ea oksijene ea mali e ka nyolohela ho 2000 mmHg, 'me phello e phahameng ea khatello ea mesifa ea oksijene e ka phahamisetsa litekanyetso tsa oksijene ho 500 mmHg. Liphello tse joalo li bohlokoa haholo ho khothalletsa pholiso ea likarabo tsa ho ruruha le ho senyeha ha microcirculatory tse hlokometsoeng libakeng tsa ischemic, hammoho le ho laola compartment syndrome.
HBOT e ka boela ea ama maemo a itšetlehileng ka sesole sa 'mele. Lipatlisiso li bontša hore HBOT e ka hatella li-syndromes tsa autoimmune le likarabo tsa 'mele tsa ho itšireletsa mafung tse bakoang ke antigen, ho thusa ho boloka mamello ea graft ka ho fokotsa ho potoloha ha lymphocyte le leukocyte ha ho ntse ho fetola likarabo tsa' mele oa ho itšireletsa mafung. Ho feta moo, HBOTe tshehetsa phodisoka maqeba a sa foleng a letlalo ka ho susumetsa angiogenesis, ts'ebetso ea bohlokoa bakeng sa ho hlaphoheloa ho ntlafetseng. Kalafo ena e boetse e khothalletsa ho thehoa ha collagen matrix, karolo ea bohlokoa ea ho folisa maqeba.
Tlhokomelo e khethehileng e tlameha ho fuoa tšoaetso e itseng, haholo-holo mafu a tebileng le ao ho leng thata ho a phekola a kang necrotizing fasciitis, osteomyelitis, mafu a sa foleng a lisele tse bonolo, le endocarditis e tšoaetsanoang. E 'ngoe ea lits'ebetso tse atileng haholo tsa bongaka tsa HBOT ke bakeng sa mafu a letlalo a bonojoana le osteomyelitis e amanang le maemo a tlase a oksijene a bakoang ke libaktheria tse anaerobic kapa tse hanyetsanang.
1. Matšoao a Maoto a Lefu la tsoekere
Leoto la lefu la tsoekereliso ke bothata bo atileng har'a bakuli ba lefu la tsoekere, bo ama ho fihla ho 25% ea baahi bana. Hangata tšoaetso e hlaha lisong tsena (e etsang karolo ea 40-80 lekholong ea linyeoe) 'me e lebisa ho eketsehang ha mafu le lefu. Mafu a lefu la tsoekere (DFIs) hangata a na le mafu a polymicrobial a nang le mefuta e fapaneng ea likokoana-hloko tsa anaerobic tse khetholloang. Lintlha tse fapaneng, tse kenyelletsang bofokoli ba ts'ebetso ea fibroblast, litaba tsa sebopeho sa collagen, mekhoa ea 'mele ea ho itšireletsa mafung, le ts'ebetso ea phagocyte, li ka sitisa pholiso ea maqeba ho bakuli ba lefu la tsoekere. Liphuputso tse 'maloa li bontšitse ho senyeha ha oksijene ea letlalo e le kotsi e matla ea ho khaoloa ho amanang le li-DFI.
E le e 'ngoe ea likhetho tsa hajoale bakeng sa kalafo ea DFI, HBOT e tlalehoa hore e ntlafatsa haholo litekanyetso tsa pholiso bakeng sa liso tsa maoto a lefu la tsoekere, ka mor'a moo e fokotsa tlhokahalo ea ho khaola litho le mehato e rarahaneng ea ho buuoa. Ha e fokotse feela tlhokahalo ea ts'ebetso e matla ea lisebelisoa, joalo ka opereishene ea letlapa le ho hlomathisa letlalo, empa hape e fana ka litšenyehelo tse tlase le litlamorao tse fokolang ha li bapisoa le likhetho tsa ho buoa. Thuto e entsoeng ke Chen et al. e bontšitse hore linako tse fetang 10 tsa HBOT li lebisitse ntlafatsong ea 78.3% ea litekanyetso tsa pholiso ea maqeba ho bakuli ba nang le lefu la tsoekere.
2. Necrotizing Soft Tissue Infections
Likokoana-hloko tsa Necrotizing soft tissues (NSTIs) hangata ke polymicrobial, hangata e hlahang ho tsoa ho motsoako oa likokoana-hloko tsa aerobic le anaerobic baktheria 'me hangata li amahanngoa le tlhahiso ea khase. Le hoja li-NSTI li batla li sa tloaeleha, li hlahisa sekhahla se phahameng sa ho shoa ka lebaka la tsoelo-pele ea tsona e potlakileng. Tlhahlobo le kalafo ka nako le ka nepo ke senotlolo sa ho fihlela litholoana tse ntle, 'me HBOT e khothalelitsoe e le mokhoa oa tlatsetso oa ho laola li-NSTI. Leha ho ntse ho na le likhang tse mabapi le ts'ebeliso ea HBOT ho NSTIs ka lebaka la khaello ea lithuto tse laoloang tse lebelletsoeng,bopaki bo fana ka maikutlo a hore e ka amahanngoa le litekanyetso tse ntlafetseng tsa ho phela le ho boloka litho tsa 'mele ho bakuli ba NSTI.. Phuputso ea morao-rao e bontšitse phokotso e kholo ea litekanyetso tsa batho ba shoang har'a bakuli ba NSTI ba fumanang HBOT.
1.3 Tšoaetso ea Sebaka sa Opereishene
Li-SSI li ka hlophisoa ho latela sebaka sa tlhaho sa tšoaetso 'me li ka hlaha ho tsoa ho likokoana-hloko tse fapaneng, ho kenyelletsa le libaktheria tsa aerobic le anaerobic. Ho sa tsotellehe tsoelo-pele ea mehato ea ho laola tšoaetso, e kang mekhoa ea ho thibela likokoana-hloko, tšebeliso ea lithibela-mafu tsa prophylactic, le lintlafatso mekhoeng ea ho buoa, li-SSI e ntse e le bothata bo tsitsitseng.
Tlhahlobo e 'ngoe ea bohlokoa e batlisisitse katleho ea HBOT ho thibela li-SSI tse tebileng ho opereishene ea neuromuscular scoliosis. HBOT ea pele ho ts'ebetso e ka fokotsa haholo liketsahalo tsa li-SSI le ho thusa ho folisa maqeba. Kalafo ena e sa hlaseleng e etsa hore ho be le tikoloho eo ho eona maemo a oksijene ka har'a maqeba a maqeba a phahamisitsoeng, a 'nileng a amahanngoa le ketso ea ho bolaea likokoana-hloko khahlanong le likokoana-hloko. Ho feta moo, e sebetsana le maemo a theohileng a mali le oksijene a kenyang letsoho ho nts'etsopele ea li-SSI. Ka ntle ho maano a mang a ho laola ts'oaetso, HBOT e khothalelitsoe haholo-holo bakeng sa liopereishene tse nang le tšoaetso e hloekileng joalo ka lits'ebetso tsa mala.
1.4 Licheso
Licheso ke likotsi tse bakoang ke mocheso o feteletseng, motlakase, lik'hemik'hale, kapa mahlaseli 'me li ka baka mafu a mangata le litekanyetso tsa ho shoa. HBOT e molemo ho phekola ho chesa ka ho eketsa maemo a oksijene meleng e senyehileng. Le hoja lithuto tsa liphoofolo le tsa bongaka li fana ka liphello tse fapaneng mabapi lekatleho ea HBOT kalafo ea ho chesa, phuputso e amanang le bakuli ba 125 ba ho chesa e bontšitse hore HBOT ha e bontše tšusumetso e kholo ho litekanyetso tsa batho ba shoang kapa palo ea liopereishene tse entsoeng empa e fokolitse nako e tloaelehileng ea ho folisa (matsatsi a 19.7 ha a bapisoa le matsatsi a 43.8). Ho kopanya HBOT le taolo e felletseng ea ho chesa ho ka laola sepsis ka katleho ho bakuli ba cheleng, e lebisang ho nako e khuts'oane ea pholiso le litlhoko tse fokotsehileng tsa mokelikeli. Leha ho le joalo, ho hlokahala lipatlisiso tse ngata tse lebelletsoeng ho netefatsa karolo ea HBOT taolong ea ho chesa ho hoholo.
1.5 Osteomyelitis
Osteomyelitis ke tšoaetso ea masapo kapa moko oa masapo hangata o bakoang ke likokoana-hloko tsa baktheria. Ho phekola lefu la osteomyelitis ho ka ba phephetso ka lebaka la phepelo e fokolang ea mali masapong le ho kenella ho lekanyelitsoeng ha lithibela-mafu mokong. Chronic osteomyelitis e tšoauoa ka likokoana-hloko tse phehellang, ho ruruha ho fokolang, le ho thehoa ha lesapo la necrotic. Refractory osteomyelitis e bolela mafu a sa foleng a masapo a tsoelang pele kapa a iphetang ho sa tsotellehe phekolo e nepahetseng.
HBOT e bontšitsoe hore e ntlafatsa haholo maemo a oksijene meleng ea masapo a tšoaelitsoeng. Liphuputso tse ngata tsa linyeoe le lihlopha tsa lihlopha li bontša hore HBOT e ntlafatsa liphello tsa kliniki bakeng sa bakuli ba osteomyelitis. E bonahala e sebetsa ka mekhoa e fapaneng, ho kenyelletsa ho matlafatsa ts'ebetso ea metabolic, ho hatella likokoana-hloko tsa baktheria, ho matlafatsa litlamorao tsa lithibela-mafu, ho fokotsa ho ruruha, le ho khothaletsa pholiso.ditsamaiso. Post-HBOT, 60% ho isa ho 85% ea bakuli ba nang le lefu le sa foleng, refractory osteomyelitis ba bontša matšoao a khatello ea tšoaetso.
1.6 Tšoaetso ea fungal
Lefatšeng ka bophara, batho ba fetang limilione tse tharo ba tšoeroe ke mafu a sa foleng kapa a hlaselang a fungal, a bakang mafu a fetang 600,000 selemo le selemo. Liphetho tsa kalafo bakeng sa ts'oaetso ea fungal hangata li senyeha ka lebaka la lintlha tse kang ho feto-fetoha ha boemo ba 'mele ba ho itšireletsa mafung, mafu a ka tlase, le litšobotsi tsa kokoana-hloko ea likokoana-hloko. HBOT e fetoha khetho e khahlehang ea kalafo mafung a matla a fungal ka lebaka la polokeho ea eona le tlhaho e sa hlaseleng. Liphuputso li bontša hore HBOT e ka sebetsa khahlanong le likokoana-hloko tsa fungal tse kang Aspergillus le Mycobacterium tuberculosis.
HBOT e khothaletsa litlamorao tsa antifungal ka ho thibela sebopeho sa biofilm ea Aspergillus, ka ts'ebetso e eketsehileng e hlokometsoeng ka mefuta e hlokang liphatsa tsa lefutso tsa superoxide dismutase (SOD). Maemo a hypoxic nakong ea tšoaetso ea fungal a baka mathata ho phano ea lithethefatsi tse thibelang likokoana-hloko, ho etsa hore maemo a eketsehileng a oksijene a tsoang ho HBOT e be thuso e ka bang molemo, le hoja lipatlisiso tse ling li loketse.
Thepa ea Antimicrobial ea HBOT
Tikoloho ea hyperoxic e entsoeng ke HBOT e qala liphetoho tsa 'mele le tsa biochemical tse susumetsang thepa ea antibacterial, e leng se etsang hore e be phekolo e sebetsang ea adjunct bakeng sa tšoaetso. HBOT e bontša liphello tse tsotehang khahlanong le libaktheria tsa aerobic 'me haholo-holo libaktheria tsa anaerobic ka mekhoa e kang ts'ebetso e tobileng ea bactericidal, ntlafatso ea likarabo tsa' mele oa ho itšireletsa mafung, le liphello tsa synergistic ka li-antimicrobial agents.
2.1 Liphello tse tobileng tsa Antibacterial tsa HBOT
Phello e tobileng ea antibacterial ea HBOT e bakoa haholo ke moloko oa mefuta ea oksijene e sebetsang (ROS), e kenyelletsang superoxide anions, hydrogen peroxide, hydroxyl radicals, le hydroxyl ions-tsohle tse hlahang nakong ea metabolism ea cellular.
Tšebelisano lipakeng tsa O₂ le likarolo tsa cellular ke ea bohlokoa ho utloisisa hore na ROS e etsa joang ka har'a lisele. Tlas'a maemo a itseng a bitsoang khatello ea oxidative, ho leka-lekana pakeng tsa ho thehoa ha ROS le ho senyeha ha eona hoa senyeha, e leng se lebisang ho maemo a phahameng a ROS ka liseleng. Tlhahiso ea superoxide (O₂⁻) e hlahisoa ke superoxide dismutase, eo ka mor'a moo e fetolang O₂⁻ hore e be hydrogen peroxide (H₂O₂). Phetoho ena e matlafatsoa hape ke karabelo ea Fenton, e etsang oxidize Fe²⁺ ho hlahisa hydroxyl radicals (·OH) le Fe³⁺, kahoo e qala tatelano e kotsi ea redox ea sebopeho sa ROS le tšenyo ea liselefouno.
Litlamorao tse chefo tsa ROS li shebile likarolo tsa bohlokoa tsa cellular joalo ka DNA, RNA, liprotheine le lipids. Haholo-holo, DNA ke sepheo sa mantlha sa H₂O₂-mediated cytotoxicity, kaha e senya mekhoa ea deoxyribose le ho senya metsoako ea motheo. Tšenyo ea 'mele e bakoang ke ROS e fetela ho sebopeho sa helix sa DNA, se ka hlahang ka lebaka la lipid peroxidation e bakoang ke ROS. Sena se totobatsa litlamorao tse mpe tsa maemo a phahameng a ROS ka har'a litsamaiso tsa baeloji.
Ketso ea Antimicrobial ea ROS
ROS e bapala karolo ea bohlokoa ho thibela kholo ea likokoana-hloko, joalo ka ha ho bontšoa ke moloko oa ROS o susumetsoang ke HBOT. Litlamorao tse chefo tsa ROS li lebisa ka kotloloho likarolo tsa cellular joalo ka DNA, liprotheine le lipids. Mefuta e phahameng ea oksijene e sebetsang e ka senya lipids ka kotloloho, e lebisang ho lipid peroxidation. Ts'ebetso ena e sekisetsa botšepehi ba lisele tsa lisele, ka lebaka leo, ts'ebetso ea li-receptor le liprotheine tse amanang le membrane.
Ho feta moo, liprotheine, tseo hape e leng liphofu tsa bohlokoa tsa limolek'hule tsa ROS, li na le liphetoho tse ikhethileng tsa oxidative masalla a fapaneng a amino acid joalo ka cysteine, methionine, tyrosine, phenylalanine, le tryptophan. Ka mohlala, HBOT e bontšitsoe hore e etsa hore ho be le liphetoho tsa oxidative liprotheine tse 'maloa ho E. coli, ho akarelletsa le elongation factor G le DnaK, kahoo e ama tšebetso ea lisele tsa bona.
Ho matlafatsa Tšireletso ea Tšireletso ka HBOT
Lintho tse khahlanong le ho ruruha tsa HBOTli ngotsoe, li bonts'a bohlokoa bakeng sa ho fokotsa tšenyo ea lisele le ho hatella tsoelo-pele ea tšoaetso. HBOT e ama haholo polelo ea li-cytokine le li-regulator tse ling tsa ho ruruha, tse susumetsang karabelo ea 'mele ea ho itšireletsa mafung. Litsamaiso tse fapaneng tsa liteko li hlokometse liphetoho tse fapaneng polelong ea liphatsa tsa lefutso le tlhahiso ea protheine kamora HBOT, e ka phahamisang kapa e theola maemo a kholo le li-cytokine.
Nakong ea ts'ebetso ea HBOT, ho eketseha ha maemo a O₂ ho baka mefuta e mengata ea likarabo tsa cellular, tse kang ho thibela ho lokolloa ha baemeli ba pro-inflammatory le ho khothalletsa lymphocyte le neutrophil apoptosis. Ka kakaretso, liketso tsena li matlafatsa tsamaiso ea 'mele ea ho itšireletsa mafung ho thibela likokoana-hloko, kahoo li thusa ho folisa mafu.
Ho feta moo, liphuputso li bontša hore ho eketseha ha maemo a O₂ nakong ea HBOT ho ka fokotsa polelo ea li-cytokine tse nang le pro-inflammatory, ho akarelletsa le interferon-gamma (IFN-γ), interleukin-1 (IL-1), le interleukin-6 (IL-6). Liphetoho tsena li boetse li kenyelletsa ho theola karo-karolelano ea CD4: CD8 T lisele le ho fetola li-receptor tse ling tse qhibilihang, qetellong li phahamisa maemo a interleukin-10 (IL-10), e leng bohlokoa bakeng sa ho thibela ho ruruha le ho khothalletsa pholiso.
Mesebetsi e thibelang likokoana-hloko ea HBOT e hokahane le mekhoa e rarahaneng ea likokoana-hloko. Ka bobeli li-superoxide le khatello e phahameng li 'nile tsa tlalehoa hore li khothalletsa ts'ebetso ea antibacterial e bakoang ke HBOT le neutrophil apoptosis. Ka mor'a HBOT, ho phahama ho hlakileng ha maemo a oksijene ho ntlafatsa bokhoni ba bactericidal ba li-neutrophils, karolo ea bohlokoa ea karabelo ea 'mele ea ho itšireletsa mafung. Ho feta moo, HBOT e hatella neutrophil adhesion, e leng lipakeng tsa ho sebelisana ha β-integrins ho li-neutrophils tse nang le li-intercellular adhesion molecules (ICAM) liseleng tsa endothelial. HBOT e thibela mosebetsi oa neutrophil β-2 integrin (Mac-1, CD11b / CD18) ka mokhoa o hlophisitsoeng oa nitric oxide (NO), o tlatsetsang ho falla ha li-neutrophils sebakeng sa tšoaetso.
Rearrangement e nepahetseng ea cytoskeleton ea hlokahala bakeng sa li-neutrophils ho atleha phagocytize likokoana-hloko. S-nitrosylation ea actin e bontšitsoe hore e susumetsa actin polymerization, e ka 'nang ea nolofatsa mosebetsi oa phagocytic oa li-neutrophils ka mor'a phekolo ea pele ea HBOT. Ho feta moo, HBOT e khothalletsa apoptosis meleng ea T ea batho ka litsela tsa mitochondrial, 'me ho tlalehoa lefu le potlakileng la lefu la lymphocyte post-HBOT. Ho thibela caspase-9-ntle le ho ama caspase-8-e bontšitse liphello tsa immunomodulatory tsa HBOT.
The Synergistic Effects of HBOT with Antimicrobial Agents
Lits'ebetsong tsa bongaka, HBOT hangata e sebelisoa hammoho le lithibela-mafu ho loantša tšoaetso ka katleho. Boemo ba hyperoxic bo finyelloang nakong ea HBOT bo ka susumetsa katleho ea li-antibiotics tse itseng. Lipatlisiso li fana ka maikutlo a hore litlhare tse itseng tsa bactericidal, tse kang β-lactam, fluoroquinolones, le aminoglycosides, ha li sebetse feela ka mekhoa ea tlhaho empa hape li itšetlehile ka mokhoa o itseng oa metabolism ea aerobic ea baktheria. Ka hona, boteng ba oksijene le litšobotsi tsa metabolism ea likokoana-hloko ke tsa bohlokoa ha ho hlahlojoa liphello tsa phekolo ea lithibela-mafu.
Bopaki bo bongata bo bontšitse hore maemo a tlaase a oksijene a ka eketsa khanyetso ea Pseudomonas aeruginosa ho piperacillin/tazobactam le hore tikoloho e tlaase ea oksijene e boetse e tlatsetsa ho eketseha ha khanyetso ea Enterobacter cloacae ho azithromycin. Ka lehlakoreng le leng, maemo a mang a hypoxic a ka eketsa kutloisiso ea baktheria ho lithibela-mafu tsa tetracycline. HBOT e sebetsa e le mokhoa o sebetsang oa ho alafa ka ho susumetsa metabolism ea aerobic le reoxygenating li-tissue tse nang le tšoaetso ea hypoxic, ka mor'a moo e eketsa kutloisiso ea likokoana-hloko ho lithibela-mafu.
Lithutong tsa pele, motsoako oa HBOT-o tsamaisoang habeli ka letsatsi bakeng sa lihora tse 8 ho 280 kPa-hammoho le tobramycin (20 mg/kg/letsatsi) o fokolitse haholo meroalo ea baktheria ho Staphylococcus aureus infectious endocarditis. Sena se bontša bokhoni ba HBOT e le phekolo e thusang. Lipatlisiso tse ling li senotse hore tlas'a khatello ea 37 ° C le 3 ATA bakeng sa lihora tsa 5, HBOT e ile ea ntlafatsa ka ho khetheha liphello tsa imipenem khahlanong le Pseudomonas aeruginosa e tšoaelitsoeng ke macrophage. Ho phaella moo, mokhoa o kopantsoeng oa HBOT o nang le cephalolin o fumanoe o atlehile ho phekola Staphylococcus aureus osteomyelitis ka mehlala ea liphoofolo ha e bapisoa le cephalolin feela.
HBOT e boetse e eketsa haholo ketso ea bactericidal ea ciprofloxacin khahlano le Pseudomonas aeruginosa biofilms, haholo kamora metsotso e 90 ea ho pepeseha. Ntlafatso ena e hlahisoa ke ho thehoa ha mefuta ea "endogenous reactive oxygen" (ROS) 'me e bonts'a kutlo e matla ho liphetoho tse sa sebetseng tsa peroxidase.
Mehlala ea pleuritis e bakoang ke Staphylococcus aureus e hanyetsanang le methicillin (MRSA), phello ea tšebelisano ea vancomycin, teicoplanin, le linezolid e nang le HBOT e bontšitse katleho e eketsehileng khahlanong le MRSA. Metronidazole, lithibela-mafu tse sebelisoang haholo ho alafa mafu a anaerobic le polymicrobial a matla joalo ka mafu a lefu la tsoekere (DFIs) le ts'oaetso ea sebaka sa ho buoa (SSIs), e bontšitse katleho e phahameng ea antimicrobial tlasa maemo a anaerobic. Lithuto tsa nako e tlang li loketse ho hlahloba litlamorao tsa synergistic antibacterial tsa HBOT hammoho le metronidazole maemong a bobeli a vivo le in vitro.
The Antimicrobial Efficacy of HBOT on Resistant Bacteria
Ka ho iphetola ha lintho le ho ata ha mefuta e hanyetsanang, lithibela-mafu tse tloaelehileng hangata li lahleheloa ke matla a tsona ha nako e ntse e ea. Ho feta moo, HBOT e ka 'na ea ipaka e le ea bohlokoa ho phekoleng le ho thibeleng mafu a bakoang ke likokoana-hloko tse hanyetsanang le lithethefatsi, e leng leano la bohlokoa ha phekolo ea lithibela-mafu e hlōleha. Lithuto tse ngata li tlalehile litlamorao tse kholo tsa bactericidal tsa HBOT ho libaktheria tse hanyetsanang le bongaka. Mohlala, kopano ea metsotso e 90 ea HBOT ho 2 ATM e fokolitse kholo ea MRSA haholo. Ho feta moo, ka mefuta ea karo-karolelano, HBOT e ntlafalitse litlamorao tsa antibacterial tsa lithibela-mafu tse fapaneng khahlano le tšoaetso ea MRSA. Litlaleho li tiisitse hore HBOT e sebetsa hantle ho phekola osteomyelitis e bakoang ke Klebsiella pneumoniae e hlahisang OXA-48 ntle le ho hloka lithibela-mafu leha e le life tse tlatsetsang.
Ka kakaretso, phekolo ea oksijene ea hyperbaric e emela mekhoa e mengata ea ho laola tšoaetso, e matlafatsang karabelo ea 'mele ea ho itšireletsa mafung ha e ntse e eketsa katleho ea li-antimicrobial agents tse teng. Ka lipatlisiso tse felletseng le nts'etsopele, e na le bokhoni ba ho fokotsa litlamorao tsa ho hanyetsa lithibela-mafu, ho fana ka tšepo ntoeng e tsoelang pele khahlanong le tšoaetso ea baktheria.
Nako ea poso: Feb-28-2025